Michael Clarke has succumbed to a 'signifcant hamstring injury' and will be replaced by Phil Hughes for the one-day series in the UAE.
Cricket Australia's National Selection Panel confirmed Hughes as Clarke's replacement on on Wednesday morning.
Clarke injured his hamstring at training prior to Australia's first match of the recent tri-series in Zimbabwe, then aggravated the problem in his first game of the tour, and scans have since revealed tendon damage in the affected area.
"Since returning to Australia Michael has had a series of investigations that have confirmed a significant hamstring injury," said Cricket Australia physiotherapist Alex Kountouris.
"Importantly, the scans have demonstrated tendon damage which complicates the recovery from this injury.
"As such, he will not recover in time to be available for the ODI series in the UAE.
"We are hopeful that he will be available for the Test series but this will be determined at a date closer to the first Test."