Mitchell Johnson claimed three wickets to leave Pakistan 4-219 at stumps, on a slow opening day of the first Test in Dubai.
After winning the toss and electing to bat Pakistan lost Ahmed Shehzad (3) and Mohammad Hafeez (0) within the first 19 balls of the match.
Pakistan's Azhar Ali (53) and Younis Khan (106) then combined for a patient stand of 108, before the former became Johnson's second victim of the day.
Johnson picked up three of Australia's wickets and was the most economical bowler of the day with 13 maidens in his 20 overs at a rate of 1.10 runs per over.
Peter Siddle (1-27) and debutant Mitchell Marsh (0-18) also both had economical run rates going for 1.58 and 1.68 runs per over respectively.
Pakistan Captain Misbah ul-Haq (34*) and Asad Shafiq (9*) will be the batsmen returning to the crease when play resumes on Thursday.